Overview

This is the analysis of white matter dsi studio connectometry for Maze and Loop

Methods

Participants

  • Total number of scans = 120 (males and females)

  • Total scans used in analysis= 118

  • Excluded subs 329 and 372 from analyses due to bad behavior data and Subject 347 failed quality control check in DSI

  • Several subjects removed because they did not have rad3 score

Maze Accuracy and Path Efficiency * All subjects = 82 * Men = 22 * Women = 60 * Stage * Pre = 23 * Peri = 20 * Post = 17

Scan parameters

  • Locations from UCSB and UCI

QSIprep

  • Version used: 0.16.0RC3

  • The following parameters were used

    • dwi_denoise_window 5
    • hmc_model 3dSHORE
    • hmc-transform Rigid
    • shoreline_iters 2
      DSI Studio

  • Version and tags used via singularity container: chen-2022-07-31

  • Parameters

    • T-threshold = 2.5
    • Length = 25
    • Permutation = 4,000
    • pruning 4
    • non normalized QA
Connectronomy analysis methods write up
A diffusion spectrum imaging scheme was used, and a total of 128 diffusion sampling were acquired.
The maximum b-value was 4990 s/mm². The in-plane resolution was 1.8 mm. The slice thickness was
1.8 mm. The accuracy of b-table orientation was examined by comparing fiber orientations with those of a population-averaged template (Yeh et al. Neuroimage, 2018). The b-table was flipped by The diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction (Yeh et al., Neuroimage, 58(1):91-9, 2011) to obtain the spin distribution function (Yeh et al., IEEE TMI, ;29(9):1626-35, 2010). A diffusion sampling length ratio of 1.25 was used. The output resolution in diffeomorphic reconstruction was 1.8 mm isotropic. The tensor metrics were calculated using DWI with b-value lower than 1750 s/mm². The quantitative anisotropy was extracted as the local connectome fingerprint (LCF, Yeh et al. PLoS Comput Biol 12(11): e1005203) and used in the connectometry analysis.


Diffusion MRI connectometry (Yeh et al. NeuroImage 125 (2016): 162-171) was used to derive the correlational tractography that has QA, MD, AD, and RD correlated with Maze Accuracy and Loop variables. A nonparametric Spearman partial correlation was used to derive the correlation, and the effect of sex, age_scan_years, and repo_status was removed using a multiple regression model. The total number of subjects varied on analysis (See Analyses and Final sample sizes above). A T-score threshold of 2.5 was assigned and tracked using a deterministic fiber tracking algorithm (Yeh et al. PLoS ONE 8(11): e80713, 2013) to obtain correlational tractography. A seeding region was placed at whole brain (39,49,29) .

The tracks were filtered by topology-informed pruning (Yeh et al. Neurotherapeutics, 16(1), 52-58, 2019) with 4 iteration(s). A length threshold of 25 voxel distance was used to select tracks. To estimate the false discovery rate, a total of 4000 randomized permutations were applied to the group label to obtain the null distribution of the track length.







Results

Maze Accuracy



Summary

A total of 82 diffusion MRI scans were included in the connectometry database. For the connectometry analysis, age, sex and repo status were listed as covariates. All subjects displayed Positive Correlations and negative correlations between tracts with QA and Maze accuracy.Tracts in the fornix with MD and RD displayed Positive Correlations relationships with Maze accuracy. AD displayed a negative relationship between tracts in the fornix and maze accuracy. All together the results suggest that increased diffusion (Md and RD) are associated with increased performance in scores in midlife participants and these associations are found in regions associated with spatial navigation. When split by sex, Men displayed a negative association between maze performance and a majority of tracts in the corpus callosum with QA. For AD, RD, and MD, men displayed significant Positive correlations relationships between performance. Altogether it suggests that better maze accuracy is associated with increased diffusion in midlife men. Women displayed the opposite, tracts in the fornix with QA were positively associated with performance while tracts in the fornix, cingulum, and cerebellum and with AD,RD, and MD were negatively associated with performance. Suggesting that more specific diffusion is associated with better maze accuracy. Next, Menopause stages were analyzed separately. Pre menopausal women displayed both positive correlations and negative correlations with QA while tracts with AD,RD and MD displayed negative relationships. Peri menopausal women displayed Positive Correlations associations in tracts with QA, MD, RD, and AD and performance. This suggests that in peri menopasual women, maze accuracy is associated with increased diffusion in tracts on the fornix, cerebellum, and cingulum. Post menopausal women displayed both positive correlations and negative associations between acc and QA. Post menopausal women displayed Positive Correlations and negative associations with QA< MD, RD, and AD and maze accuracy. A majority of tracts in the fornix with AD,MD, and RD were positively associated with maze accuracy

QA

Summary of results

There were both Positive Correlations and negative correlations between QA and maze performance when all subjects were included in the analysis. When men were analyzed separately, men displayed more negatively associated correlations between QA and maze performance. Women displayed tracts with predominantly Positive Correlations correlations between QA and performance. When split by menopause stagge, Pre and post displayed both Positive Correlations and negative correlations while peri displayed only Positive Correlations correlations with performance.









All subjects

Positive Correlations ( FDR= 0.043228)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 164 57.5732 6.71347 2038
Corpus_Callosum_Forceps_Minor 25 51.92 4.31996 761
Corpus_Callosum_Forceps_Major 22 51.7273 4.37326 777
Cingulum_Parolfactory_R 19 51.6842 3.00273 366
Cingulum_Frontal_Parietal_L 4 52 1.96066 157



Negative Correlations ( FDR= 0.122807)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Superior_Longitudinal_Fasciculus2_R 95 56.5053 6.13252 1669
Corpus_Callosum_Forceps_Major 88 54.1364 5.88189 1471
Corpus_Callosum_Tapetum 73 52.5205 6.26296 1618
Cerebellum_L 66 52.8182 5.28801 1160
Cingulum_Frontal_Parietal_L 18 52.8889 2.63768 289
Corpus_Callosum_Forceps_Minor 11 53.4545 2.54066 271
Corpus_Callosum_Body 10 51.4 2.73512 302
Cingulum_Frontal_Parahippocampal_L 5 53.6 1.82363 140
Middle_Cerebellar_Peduncle 5 51.6 2.39777 233



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy


Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy







Men

Positive Correlations (FDR = 0.018519)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 38 51.8947 4.63073 874
Corpus_Callosum_Body 2 50 1.34462 71



Negative Correlations (FDR = 0.001161)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 1024 57.0742 14.1861 9021
Middle_Cerebellar_Peduncle 936 58.109 12.1046 6687
Cerebellum_R 340 54.8059 11.0575 5263
Fornix_R 207 56.029 5.50588 1334
Corpus_Callosum_Body 139 53.9712 7.94987 2679
Corpus_Callosum_Tapetum 86 54.4186 6.54345 1830
Corpus_Callosum_Forceps_Major 86 55 6.76172 1975
Inferior_Fronto_Occipital_Fasciculus_L 51 54.2745 4.50209 864
Inferior_Cerebellar_Peduncle_R 36 58.7222 4.55522 957
Inferior_Longitudinal_Fasciculus_L 33 60.1818 4.03615 770



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in men


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in men


Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in men







Women

Positive Correlations Corrs (FDR = 0.000263)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 454 58.5374 7.88027 2855
Corpus_Callosum_Forceps_Major 198 57.9596 8.40786 3218
Cingulum_Frontal_Parietal_L 169 53.4675 7.14867 2146
Cingulum_Frontal_Parietal_R 151 55.0729 6.58747 1877
Inferior_Fronto_Occipital_Fasciculus_R 149 58.8188 6.25945 1810
Uncinate_Fasciculus_R 132 60.9848 5.96106 1702
Middle_Cerebellar_Peduncle 130 54.0769 6.16263 1613
Corticospinal_Tract_L 98 53.898 7.61388 2454
Cingulum_Parolfactory_R 94 57.9149 5.0565 1163
Middle_Longitudinal_Fasciculus_R 76 51.7368 4.47577 814
Cingulum_Frontal_Parahippocampal_L 51 52.1177 5.31424 1156
Superior_Longitudinal_Fasciculus2_R 49 54.5714 4.16638 744
Superior_Longitudinal_Fasciculus1_L 40 51.5 4.43895 797
Cerebellum_L 40 51.65 4.27395 741
Corticospinal_Tract_R 38 55.8421 3.62712 577
Corpus_Callosum_Forceps_Minor 29 53.7931 4.3542 801
Corticostriatal_Tract_Superior_L 25 51.52 3.79904 584



Negative Correlations Corrs (FDR = 0.002809)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 142 53.5493 6.60176 1833
Corpus_Callosum_Forceps_Major 135 54.8593 6.0537 1579
Corpus_Callosum_Body 98 52.4082 5.89418 1430
Corpus_Callosum_Forceps_Minor 76 51.8684 5.68154 1315
Cingulum_Frontal_Parietal_L 75 54.08 4.71935 946
Cingulum_Parolfactory_R 32 55.8125 3.56465 557
Cingulum_Frontal_Parahippocampal_L 24 57.5 2.99467 405
Corticospinal_Tract_L 17 60.4706 3.21204 490
Superior_Longitudinal_Fasciculus2_R 10 58 2.72798 339



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in women

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in women

Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in women







pre

Positive Correlations Corrs (FDR = 0.044369)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 187 55.4332 7.16168 2233
Cingulum_Frontal_Parietal_R 92 55.2826 5.08343 1122
Fornix_L 57 55.5789 4.93244 1062
Superior_Longitudinal_Fasciculus1_L 23 51.4783 3.02104 369
Middle_Cerebellar_Peduncle 13 54.4615 3.4258 502
Cingulum_Parolfactory_R 6 62.3333 2.42965 289
Corpus_Callosum_Tapetum 5 54.4 1.71045 125
Corpus_Callosum_Forceps_Major 5 52.8 1.70817 121



Negative Correlations Corrs (FDR = 0.011788)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 488 55.5902 8.95216 3499
Corpus_Callosum_Forceps_Major 276 58.6956 6.83875 2156
Cingulum_Frontal_Parietal_L 124 55.4677 5.24401 1198
Corpus_Callosum_Tapetum 111 54.6486 6.39264 1754
Cingulum_Parolfactory_R 75 55.3867 4.2399 782
Corticospinal_Tract_R 52 57.0385 4.4447 885
Corpus_Callosum_Body 42 52.5714 4.32403 772
Cingulum_Frontal_Parahippocampal_L 34 54.7647 3.60182 558
Cingulum_Parolfactory_L 27 52.6667 4.16629 718
Uncinate_Fasciculus_R 25 56.4 3.44922 527
NA NA NA NA NA



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in pre-menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in pre-menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in pre-menopausal women








peri

Positive Correlations Corrs (FDR = 0.000231)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_L 863 57.1031 11.1693 5595
Corticospinal_Tract_R 661 57.1528 9.86907 4372
Corpus_Callosum_Forceps_Minor 444 59.3964 10.6156 5257
Cingulum_Frontal_Parietal_L 143 53.8462 6.18921 1620
Superior_Longitudinal_Fasciculus2_R 106 54.1132 5.56457 1316
Medial_Lemniscus_R 86 55.9302 5.9344 1547
Cingulum_Parolfactory_R 78 60.2051 4.52456 968
Cingulum_Frontal_Parahippocampal_L 44 53.0455 4.53546 857
Corpus_Callosum_Forceps_Major 43 53.7674 4.1148 715
Medial_Lemniscus_L 39 53.8462 4.6869 929



Negative Correlations Corrs (FDR = 1.000000)

No Significant Findings



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in peri-menopausal women



Glass Brain displaying tracts that had QA positively correlated with maze learning accuracy in peri-menopausal women







post

Positive Correlations Corrs (FDR = 0.000418)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 532 57.594 9.34469 3950
Corpus_Callosum_Tapetum 531 55.1224 11.0195 5257
Inferior_Longitudinal_Fasciculus_L 88 58.4545 5.95305 1627
Corticospinal_Tract_R 80 55.925 4.82603 1023
Corticospinal_Tract_L 76 56.2368 5.44395 1309
Inferior_Fronto_Occipital_Fasciculus_L 43 55.3023 4.49092 876
Cingulum_Frontal_Parietal_R 37 52.5405 3.9382 640
Cerebellum_L 29 52.4138 5.18803 1108
Corticopontine_Tract_Occipital_L 26 57.9231 3.6648 611
Corticostriatal_Tract_Posterior_L 25 53.84 4.12924 721



Negative Correlations Corrs (FDR = 0.015152)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 32 56.875 5.31736 1263
Cingulum_Parolfactory_R 8 55.75 1.64856 119
Arcuate_Fasciculus_L 3 52 1.41697 82
Corpus_Callosum_Forceps_Major 2 52 1.46789 88



Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in post-menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in post-menopausal women


Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in post-menopausal women








Box plots







MD

Summary of results

DSI was run on all subjects, with sex and age listed as covariates. There were Positive Correlations correlations between MD values in the Fornix (L&R) and performance. Using a sex stratified apporoach we viewed the relationship between white matter and performance in men and women separately. Men, displayed a majortiy of Positive Correlations correlations between tracts with MD and accuracy. Specifically in regions associated with navigation such as the fornix (L & R). Women, displayed a majortiy of negative correlations between tracts with MD and accuracy. Specifically in regions associated with navigation such as the fornix (L & R), and cerebelllum. We then investigated the relationship of white matter and performance when splitting by menopause stage. Pre menopause women displayed a majortiy of negative correlations between tracts with MD and accuracy in the fornix(L&R) and corpus callosum. Peri menopause women displayed a majority of Positive Correlations correlations between tracts with MD and accuracy in the fornix(L&R) cerebellum and cingulum. Post Menopause displayed both Positive Correlations and negative relationships between MD and performance. The majority of tracts with Positive Correlations correlations were in the fornix, while a majority of the negative correlations were found in tracts in the parietal cortex and cerebellum.






All subjects

Positive Correlations Corrs (FDR = 0.124661)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 402 54.3731 7.84916 2631
Fornix_L 272 54.5515 7.16903 2202
Thalamic_Radiation_Superior_L 1 58 1.22179 68



Negative Corrs (FDR = 1.000000)

No significant findings



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with Maze learning accuracy


Glass Brain displaying tracts that had MD positively correlated with maze learning accuracy in








Men

Positive Correlations Corrs (FDR = 0.012068)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 957 55.3521 9.27769 3742
Fornix_L 473 56.1818 8.32892 3061
Thalamic_Radiation_Superior_L 94 58.2979 5.05501 1170
Superior_Longitudinal_Fasciculus2_R 89 57.3483 5.31629 1273
Arcuate_Fasciculus_R 52 56 5.30758 1239
Thalamic_Radiation_Superior_R 28 55.7857 3.84278 647



Negative Correlations Corrs (FDR = 0.075269)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 43 54.3256 4.00388 684



Figures

Slice overlay image displaying ROIs with tracts that had MD positively correlated with Maze learning accuracy in men


Glass Brain displaying tracts that had MD positively and negatively correlated with maze learning accuracy in men








Women

Positive Correlations Corrs (FDR = 0.071429)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 8 53.5 2.18169 200
Fornix_L 2 52 1.54113 97
Negative Correlations Corrs (FDR = 0.061328)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 319 56.9843 7.30304 2387
Cerebellum_L 131 52.8244 5.16782 1108
Fornix_R 126 55.7778 4.78015 1001
Cingulum_Frontal_Parietal_L 39 58.4615 3.37175 522
Thalamic_Radiation_Anterior_L 19 53.4737 2.78608 326
Cerebellum_R 13 53.3846 2.64351 293



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze learning accuracy in women


Glass Brain displaying tracts that had MD negatively correlated with maze learning accuracy in women








pre

Positive Correlations Corrs (FDR = 1.000000)

No significant findings



Negative Correlations Corrs (FDR = 0.002473)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1210 58.0314 10.1267 4674
Fornix_R 131 54.9924 5.98866 1549
Corpus_Callosum_Forceps_Major 72 55.1389 5.76243 1438
Cerebellum_L 60 53.5 4.57375 879
Thalamic_Radiation_Superior_L 54 58 4.71337 1012
Corpus_Callosum_Tapetum 49 54.898 4.45047 854
Corpus_Callosum_Body 26 52 3.53723 511



Figures

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze learning accuracy in pre-menopausal women


Glass Brain displaying tracts that had MD negatively correlated with maze learning accuracy in pre-menopausal women









peri

Positive Correlations Corrs (FDR = 0.000106)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1277 59.8168 9.05144 3849
Fornix_R 531 57.7439 7.73441 2713
Cerebellum_L 488 53.291 8.99837 3389
Cerebellum_R 230 55.1304 8.90812 3436
Cingulum_Frontal_Parietal_L 203 56.9458 5.33924 1275
Thalamic_Radiation_Superior_L 121 57.5207 5.92322 1585
Corpus_Callosum_Forceps_Major 82 53.6341 4.98072 1045
Cingulum_Frontal_Parahippocampal_L 42 58.6667 4.14855 793



Negative Correlations Corrs (FDR = 0.351351)

No significant findings



Figures

Slice overlay image displaying ROIs with tracts that had MD positvely correlated with Maze learning accuracy in peri-menopausal women


Glass Brain displaying tracts that had MD positively correlated with maze learning accuracy in peri-menopausal women








post

Positive Correlations Corrs (FDR = 0.000106)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 670 55.5164 8.05206 2827
Fornix_L 348 54.6207 6.29878 1702
Thalamic_Radiation_Superior_L 32 54.0625 3.75909 600
Corpus_Callosum_Tapetum 13 52.1539 3.13274 402



Negative Correlations Corrs (FDR = 0.351351)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 256 52.5547 8.66343 3098
Superior_Longitudinal_Fasciculus2_R 246 57.0163 7.45086 2486
Cerebellum_L 203 52.7882 7.8763 2572
Inferior_Longitudinal_Fasciculus_L 159 56.1384 8.01441 2832
Arcuate_Fasciculus_L 109 57.8349 6.97835 2212
Arcuate_Fasciculus_R 82 53.7561 6.83777 1974
Corticostriatal_Tract_Posterior_R 71 53.0704 5.82443 1414
Inferior_Fronto_Occipital_Fasciculus_L 47 56.5106 4.93974 1083
Superior_Longitudinal_Fasciculus2_L 40 54.9 5.27545 1200



Figures

Slice overlay image displaying ROIs with tracts that had MD positvely correlated with Maze learning accuracy in post-menopausal women


Glass Brain displaying tracts that had MD positively correlated with maze learning accuracy in pre-menopausal women







combined peri/post












Box plots

RD

Summary of results

All subjects analyzed, tracts in the fornix were positively associated with acc. In Men, tracts in the fornix were positvely associated with acc. Women showed tracts in the fornix were negatively associated with acc. Pre menopausal women showed a similar findings to women with negative correlations in tracts in the fornix. Peri menopasual women showed results similar to men, with tracts in the fornix positively associated. Post menopausal women displayed Positive Correlations and negative associations with a majority of Positive Correlations tracts located in the fornix and negative tracts in the cerebellum.






All subjects

Positive Correlations ( FDR= 0.146417 )

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 424 54.2311 7.73295 2547
Fornix_L 159 53.044 6.32374 1666
Thalamic_Radiation_Superior_R 11 52 2.51341 258



Negative Correlations ( FDR= 1.000000)

No significant findings



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze learning accuracy


Glass Brain displaying tracts that had RD positively correlated with maze learning accuracy









Men

Positive Correlations Corrs (FDR = 0.019254)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 1152 55.7396 9.34491 3823
Fornix_L 507 56.2209 8.34911 3078
Thalamic_Radiation_Superior_L 71 59.6338 4.74158 1053
Thalamic_Radiation_Superior_R 20 54.9 3.35728 486



Negative Correlations Corrs (FDR = 0.800000)

No Significant Findings



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze learning accuracy in men



Glass Brain displaying tracts that had RD positively correlated with maze learning accuracy in men







Women

Positive Correlations Corrs (FDR = 0.083333)

No Significant Findings



Negative Correlations Corrs (FDR = 0.074362)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 280 55.8643 7.1595 2249
Cerebellum_L 94 52.5106 4.81963 958
Fornix_R 64 54.5 4.4352 842
Cingulum_Frontal_Parietal_L 48 59.4167 2.96771 411
Corpus_Callosum_Forceps_Major 28 53.4286 3.45531 501
Thalamic_Radiation_Anterior_L 20 54.1 2.95092 370
Corpus_Callosum_Body 7 50.5714 2.76655 304



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze learning accuracy in women


Glass Brain displaying tracts that had RD negatively correlated with maze learning accuracy in women









pre

Positive Correlations Corrs (FDR = 1.000000)

No Significant Findings



Negative Correlations Corrs (FDR = 0.010636)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1265 58.4553 10.1983 4775
Fornix_R 193 56.0622 6.8383 2059
Corpus_Callosum_Forceps_Major 64 56.4062 5.0883 1147
Corpus_Callosum_Tapetum 53 55.6226 4.78681 1001
Cerebellum_L 22 52.6364 3.51923 512
Corpus_Callosum_Body 17 51.4118 3.41534 471



Figures

Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze learning accuracy in pre-menopausal women


Glass Brain displaying tracts that had RD negatively correlated with maze learning accuracy in pre-menopausal women








peri

Positive Correlations Corrs (FDR = 0.000248)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 805 58.9615 7.82847 2838
Fornix_R 322 56.9938 7.13375 2278
Cerebellum_L 288 52.6181 7.71377 2459
Cerebellum_R 94 55.5957 5.86111 1500
Thalamic_Radiation_Superior_L 42 58.8095 4.08032 769
Cingulum_Frontal_Parietal_L 38 57.4211 4.03704 735
Corpus_Callosum_Forceps_Major 28 55.1429 3.38075 495
Cingulum_Frontal_Parahippocampal_L 21 62 3.37298 554



Negative Correlations Corrs (FDR = 0.000000)

No Significant Findings



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze learning accuracy in pre-menopausal women


Glass Brain displaying tracts that had RD positively correlated with maze learning accuracy in pre-menopausal women








post

Positive Correlations Corrs (FDR = 0.000777)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 606 55.2706 7.80881 2647
Fornix_L 262 54.2519 5.83353 1450
Thalamic_Radiation_Superior_L 21 55.5238 3.23369 456
Corpus_Callosum_Tapetum 14 52.7143 3.32964 459



Negative Correlations Corrs (FDR = 0.040343)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 228 52.7895 8.23841 2814
Cerebellum_L 171 52.7251 7.92226 2599
Corticostriatal_Tract_Posterior_R 99 54.0404 6.24446 1655
Inferior_Longitudinal_Fasciculus_L 69 55.2464 6.37245 1762
Corpus_Callosum_Forceps_Major 56 53.8929 4.97588 1048
Superior_Longitudinal_Fasciculus2_R 42 54.0476 4.8122 983
Frontal_Aslant_Tract_L 35 59.7714 4.38826 904
Middle_Longitudinal_Fasciculus_R 19 53.7895 4.37874 810
Arcuate_Fasciculus_R 18 52.7778 3.54186 520
Inferior_Fronto_Occipital_Fasciculus_L 17 55.5294 3.99483 696
Corpus_Callosum_Tapetum 10 57.6 3.31786 498
Inferior_Fronto_Occipital_Fasciculus_R 9 50.6667 2.80457 313



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze learning accuracy in post-menopausal women


Glass Brain displaying tracts that had RD positively and negatively correlated with maze learning accuracy in post-menopausal women











peri post combination

Positive Correlations Corrs (FDR = 0.000994)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 369 55.0406 6.07426 1595
Fornix_R 140 55.4857 6.28062 1719



Negative Correlations Corrs (FDR = 0.009259)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Positive Correlation 510 55.1529 8.82166 3371
Cerebellum_R 55 52.2182 4.94532 1003



Figures

Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze learning accuracy in peri and post-menopausal women


Glass Brain displaying tracts that had RD positively and negatively correlated with maze learning accuracy in post-menopausal women













Maze Path Efficiency

We would expect that lower QA values would correspond to higher PE scores. higher PE scores indicate worse efficiency

  • All subjects
    • Negative correlations in corpus callosum and cingulum. Meaning that those with higher QA values had better efficiency scores ( correct trial only also had negatve only.)
    • MD exhibited negative correlations suggesting lower MD corresponded to higher scores. Lower diffusivity corresponded to worse efficincy ( same for correct trials only)
    • AD had tracts but they were less than 10. nothing significant for correct trials
    • RD was negative only correlations ( Same with corect trials only : Fornix only)
  • Men
    • QA had tracts that were positively and negatively correlated
    • MD was negatively correlated with PE scores. ( Correct only had pos and negative)
    • AD displayed negative correlations suggesting more specific diffusivity corresponded to better efficicency ( correct trials had pos and neg)
    • RD had negative correlations
  • Women
    • QA displayed pos and negative correlations but mostly negative ( same for correct trials)
    • MD displayed pos and negative correlations but mostly negative corrs. (correct only did not have any correlations
    • AD displayed pos and negative correlations but mostly negative corrs (correct only did not have any correlations) -RD displayed pos and negative correlations but mostly negative corrs (correct showed same po/neg)
  • Pre
    • QA displayed pos and negative correlations but mostly negative ( same for correct trials)
    • MD displayed pos and negative correlations
    • AD displayed negative correlations
    • RD displayed negative correlations
  • Peri
    • QA displayed negative correlations
    • MD displayed pos and negative correlations with tracts in the fornix displaying a pos relationship
    • AD displayed pos and negative correlations with tracts in the fornix displaying a pos relationship
    • RD displayed pos and negative correlations with tracts in the fornix displaying a pos relationship
  • Post
    • QA displayed negative correlations
    • MD displayed pos and negative correlations
    • AD displayed pos and negative correlations with most being negative
    • RD displayed pos and negative correlations
  • Peri and Post
    • QA displayed negative correlations
    • MD displayed pos and negative correlations
    • AD displayed positive
    • RD displayed pos and negative correlations but mostly positive
  • Men

QA

All Subjects

Positive Correlations ( FDR= 0.003279)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Vermis 98 52.3673 5.07186 1058
Cerebellum_L 44 55.5 4.33197 818



Negative Correlations ( FDR= 0.001618)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cingulum_Frontal_Parietal_L 170 55.0941 5.94049 1527
Corpus_Callosum_Body 99 53.0101 6.49808 1758
Corpus_Callosum_Forceps_Minor 92 52.9348 5.16942 1111
Corpus_Callosum_Tapetum 69 51.0435 6.45035 1668
Cingulum_Frontal_Parahippocampal_L 15 56.9333 3.54519 562



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze Path Eff


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff


Glass Brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff







Men

Positive Correlations ( FDR= 0.005510)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 1485 58.5616 14.0311 9055
Cerebellum_R 149 53.6242 8.67022 3166
Vermis 113 52.9027 7.13126 2113
Middle_Cerebellar_Peduncle 26 63.9231 3.89331 761
Corticostriatal_Tract_Posterior_L 22 52.6363 3.71321 570
Inferior_Fronto_Occipital_Fasciculus_L 16 53 3.1953 425
Inferior_Longitudinal_Fasciculus_L 10 57.6 2.95864 396



Negative Correlations (FDR= 0.007274)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 511 54.955 9.54097 3929
Corpus_Callosum_Body 455 56.2725 13.373 7904
Corpus_Callosum_Forceps_Major 283 58.6148 8.20204 3097
Middle_Cerebellar_Peduncle 136 55.6618 7.19798 2265
Cingulum_Frontal_Parietal_R 94 54.3192 4.70148 943
Corpus_Callosum_Tapetum 92 54.4783 7.17385 2202
Corticospinal_Tract_R 65 54.3385 4.75516 965
Cerebellum_L 28 52.7143 4.94891 1014
Cerebellum_R 27 51.6296 4.60527 860
Cingulum_Parolfactory_R 17 56.1176 2.92078 376



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze Path Eff in men


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff in men


Glass Brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff in men







Women

Positive Correlations ( FDR= 0.007246)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Vermis 53 52.5283 4.08962 690
Cerebellum_L 10 51.8 2.73355 304



Negative Correlations (FDR= 0.000369)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cingulum_Frontal_Parietal_L 448 56.933 7.02545 2207
Inferior_Fronto_Occipital_Fasciculus_R 410 57.5122 6.55523 1941
Corpus_Callosum_Tapetum 257 53.5253 8.73424 3207
Corpus_Callosum_Body 120 54.5833 7.67004 2522
Cingulum_Frontal_Parahippocampal_L 94 58.3191 5.439 1355
Cingulum_Parolfactory_L 74 53.6487 5.12797 1108
Cingulum_Parolfactory_R 41 56.7805 3.46364 535
Corpus_Callosum_Forceps_Minor 26 51.7692 3.95812 637
Inferior_Fronto_Occipital_Fasciculus_L 16 52.875 2.54983 270
Cingulum_Frontal_Parietal_R 15 56.8 2.79701 349
Cerebellum_R 12 52.5 3.05567 385



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze Path Eff in women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff in women


Glass brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff in women







Pre

Positive Correlations ( FDR= 0.001502)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 399 59.6792 8.12332 3093
Inferior_Fronto_Occipital_Fasciculus_L 33 55.8182 3.48683 533
Middle_Cerebellar_Peduncle 32 52.9375 4.26135 755
Anterior_Commissure 11 54.3636 2.81774 339



Negative Correlations (FDR= 0.001490)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Fronto_Occipital_Fasciculus_R 146 59.5479 7.02945 2311
Cingulum_Parolfactory_R 108 59.8704 4.13502 804
Inferior_Fronto_Occipital_Fasciculus_L 75 53.7867 5.13524 1114
Corpus_Callosum_Tapetum 74 54.0811 5.86285 1460
Cingulum_Frontal_Parietal_L 43 54.4651 3.68222 580
Cingulum_Frontal_Parietal_R 42 54.6191 3.696 586
Uncinate_Fasciculus_R 14 62.1429 3.3691 554



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze Path Eff in women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff in pre- menopausal women


Glass brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff in pre-menopausal women







Peri

Positive Correlations ( FDR= 1.000000)

No Significant Correlations



Negative Correlations (FDR= 0.000374)



Figures


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff in peri-menopausal women


Glass brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff in peri-menopausal women







Post

Positive Correlations ( FDR= 0.001024)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_L 162 55.8519 6.43419 1816
Corticopontine_Tract_Parietal_L 123 60.7967 4.42508 935
Inferior_Fronto_Occipital_Fasciculus_L 65 54.3692 4.88501 1019
Corticostriatal_Tract_Posterior_L 61 54.918 4.33084 809
Thalamic_Radiation_Posterior_L 34 56.5882 4.15693 768
Vermis 34 52.7059 3.51003 510
Corticospinal_Tract_R 32 57.5 3.34069 504
Inferior_Longitudinal_Fasciculus_L 31 54.5806 3.92381 660
Cerebellum_R 29 52.8276 4.40476 805
Corticopontine_Tract_Occipital_L 18 57.7778 3.02047 414
Corticobulbar_Tract_L 17 58.9412 2.31924 249
Cerebellum_L 17 50.9412 2.73373 299



Negative Correlations (FDR= 0.001339)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cingulum_Frontal_Parietal_R 121 57.0413 4.64594 967
Corpus_Callosum_Forceps_Major 76 56.2632 4.98249 1097
Inferior_Fronto_Occipital_Fasciculus_R 62 56 4.94615 1076
Middle_Cerebellar_Peduncle 61 52 4.50809 830
Corpus_Callosum_Tapetum 50 53.36 5.00067 1048
Cingulum_Parolfactory_R 47 58.3404 3.61261 598
Inferior_Longitudinal_Fasciculus_R 27 51.5556 3.30017 441
Cingulum_Frontal_Parietal_L 26 54.1539 3.58947 548



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze Path Eff in post menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff in post-menopausal women


Glass brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff in post-menopausal women







Peri and Post

Positive Correlations ( FDR= 0.006944)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Vermis 31 52.1936 3.17026 412



Negative Correlations (FDR= 0.000330)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 497 58.2414 12.4287 7066
Inferior_Fronto_Occipital_Fasciculus_R 279 58.0932 6.96596 2214
Corpus_Callosum_Tapetum 256 56.7031 8.99339 3602
Corticospinal_Tract_R 166 54.9518 6.40399 1770
Cingulum_Frontal_Parietal_L 162 58.963 5.09257 1201
Cerebellum_R 92 54.0652 4.27215 775
Corpus_Callosum_Forceps_Major 70 60.3714 5.38898 1377
Medial_Lemniscus_R 46 55.087 5.02851 1094
Cerebellum_L 38 52.7368 3.3253 458
Corticostriatal_Tract_Superior_R 28 53.0714 4.00325 668
Cingulum_Frontal_Parahippocampal_L 22 56.3636 3.23754 464
Cingulum_Frontal_Parietal_R 22 55.5455 2.83247 350
Corticopontine_Tract_Parietal_R 21 53.8095 2.98673 377
Inferior_Longitudinal_Fasciculus_L 13 54 2.66847 302
Cingulum_Parolfactory_L 12 56.6667 2.75989 339
Corpus_Callosum_Forceps_Minor 10 52.8 2.54218 268



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze Path Eff in peri and post menopausal women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff in peri and post-menopausal women


Glass brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff in peri and post-menopausal women







MD

All Subjects

Positive Correlations ( FDR= 1.000000)

No Significant Correlations



Negative Correlations (FDR= 0.000364)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Longitudinal_Fasciculus_R 583 53.6775 11.4219 5500
Inferior_Fronto_Occipital_Fasciculus_R 546 53.2051 11.7914 5810
Corticostriatal_Tract_Posterior_R 408 53.1961 10.8219 4893
Corpus_Callosum_Tapetum 144 54.0278 7.56901 2431
Arcuate_Fasciculus_R 60 53.4 5.75901 1391
Middle_Longitudinal_Fasciculus_R 41 53.7561 5.18032 1133
Corticopontine_Tract_Occipital_R 34 53.1176 4.77448 951
Thalamic_Radiation_Posterior_R 28 52.8571 5.23339 1137
Anterior_Commissure 10 54.2 2.53243 273



Figures


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze Path Eff


Glass brain displaying tracts that had MD positively and negatively correlated with Maze Path Eff in peri and post-menopausal women







Men

Positive Correlations ( FDR= 0.242767)

No Significant Correlations



Negative Correlations (FDR= 0.001337)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Arcuate_Fasciculus_R 258 56.606 7.58533 2558
Superior_Longitudinal_Fasciculus2_R 179 58.0314 6.31395 1817
Inferior_Longitudinal_Fasciculus_R 49 62.907 3.6825 670
Corticostriatal_Tract_Posterior_R 26 53.6194 3.6466 560



Figures


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze Path Eff in men


Glass brain displaying tracts that had MD negatively correlated with Maze Path Eff in peri and post-menopausal women







Women

Positive Correlations ( FDR= 0.046512)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 32 51.375 4.12927 688
Cerebellum_L 3 52 1.92283 151



Negative Correlations (FDR= 0.00032)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 443 55.4402 8.85342 3413
Inferior_Longitudinal_Fasciculus_R 404 52.7921 9.94282 4099
Inferior_Fronto_Occipital_Fasciculus_R 353 52.4986 10.8086 4817
Corticostriatal_Tract_Posterior_R 130 52.7538 8.29665 2852
Corpus_Callosum_Tapetum 129 54.2791 7.72802 2546
Fornix_R 127 54.7402 5.61192 1354
Thalamic_Radiation_Superior_L 98 55.5306 5.13943 1152
Thalamic_Radiation_Posterior_R 54 52.9259 5.86118 1428
Arcuate_Fasciculus_R 32 54.3125 4.96371 1051
Middle_Longitudinal_Fasciculus_R 30 54.8 4.83704 1007
Corticopontine_Tract_Parietal_R 11 50.9091 3.03376 368
Anterior_Commissure 10 52.2 2.44956 246
Cerebellum_L 10 55 2.92272 369



Figures


Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze Path Eff in women


Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze Path Eff in women


Glass brain displaying tracts that had QA positively and negatively correlated with Maze Path Eff in women







Pre

Positive Correlations ( FDR= 1.000000)

No Significant Corrleations



Negative Correlations (FDR= 0.021415)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1169 55.8648 10.2358 4597
Inferior_Longitudinal_Fasciculus_R 1129 56.5651 12.4751 6914
Inferior_Fronto_Occipital_Fasciculus_R 1003 55.6012 12.6155 6950
Fornix_R 503 55.67 8.14832 2903
Corticostriatal_Tract_Posterior_R 278 55.5827 10.4487 4766
Corpus_Callosum_Tapetum 212 55.8774 9.6656 4100
Thalamic_Radiation_Superior_L 148 54.3649 6.61785 1870
Thalamic_Radiation_Posterior_R 87 56.6897 6.13902 1678
Corpus_Callosum_Forceps_Major 79 55.0127 6.47773 1813
Arcuate_Fasciculus_R 48 54.7083 5.99449 1544
Middle_Longitudinal_Fasciculus_R 48 54.1667 5.09417 1104
Medial_Lemniscus_R 46 55.8696 4.36747 837
Cerebellum_L 40 52 4.70996 906
Inferior_Fronto_Occipital_Fasciculus_L 33 51.697 4.75752 919
Corticopontine_Tract_Occipital_R 20 58.5 4.52796 942
Thalamic_Radiation_Superior_R 19 58.7368 2.84732 374
Cingulum_Frontal_Parietal_L 17 54.8235 2.37561 243
Corticopontine_Tract_Parietal_R 15 53.4667 2.38568 239
Inferior_Longitudinal_Fasciculus_L 12 53.5 3.07765 398
Anterior_Commissure 10 52.4 3.10979 398



Figures


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze Path Eff in pre-menopausal women


Glass brain displaying tracts that had MD negatively correlated with Maze Path Eff in peri and post-menopausal women







Peri

Positive Correlations ( FDR= 0.002496)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 585 56.0103 7.52352 2490
Fornix_L 273 56.9451 7.1274 2272
Cerebellum_R 89 52.2247 6.07547 1514



Negative Correlations (FDR= 002323)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 165 55.0424 7.9336 2721
Cerebellum_L 147 53.8776 7.56551 2422
Middle_Cerebellar_Peduncle 12 50.6667 3.05749 372



Figures


Slice overlay image displaying ROIs with tracts that had MD positively correlated with Maze Path Eff in peri menopausal women


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze Path Eff in peri menopausal women


Glass brain displaying tracts that had MD positively and negatively correlated with Maze Path Eff in perimenopausal women







Post

Positive Correlations ( FDR= 0.002926)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 498 52.6626 8.27028 2829
Cerebellum_R 121 52.7934 5.32334 1175



Negative Correlations (FDR= 0.002119)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cingulum_Frontal_Parietal_R 66 53.7273 4.36501 804
Cerebellum_R 45 54.1333 4.48179 854
Fornix_R 42 54.6667 3.70383 589
Thalamic_Radiation_Posterior_R 40 56.7 4.37661 853
Corpus_Callosum_Forceps_Major 24 52.75 4.03043 673
Corticostriatal_Tract_Posterior_R 22 54.8182 3.86454 643
Corpus_Callosum_Tapetum 20 54.4 3.92734 659
Arcuate_Fasciculus_R 11 56.5455 2.6801 319



Figures


Slice overlay image displaying ROIs with tracts that had MD positively correlated with Maze Path Eff in post menopausal women


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze Path Eff and post-menopausal women


Glass brain displaying tracts that had MD positively and negatively correlated with Maze Path Eff in post-menopausal women







Peri and Post

Positive Correlations ( FDR= 0.024953)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 351 51.9202 8.22402 2758
Fornix_R 326 56.2025 6.00172 1590
Cerebellum_R 101 52.6139 6.00076 1488



Negative Correlations (FDR= 0.163978)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 351 51.9202 8.22402 2758
Fornix_R 326 56.2025 6.00172 1590
Cerebellum_R 101 52.6139 6.00076 1488



Figures


Slice overlay image displaying ROIs with tracts that had MD positively correlated with Maze Path Eff in peri and post menopausal women


Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze Path Eff in peri and post-menopausal women


Glass brain displaying tracts that had MD positively and negatively correlated with Maze Path Eff in peri and post-menopausal women







AD

All Subjects

Positive Correlations ( FDR= 0.055556)

Less than 10 tracts



Negative Correlations (FDR= 0.083333)

Less than 10 tracts











Men

Positive Correlations ( FDR= 0.677419)

No Significant Findings



Negative Correlations (FDR= 0.183673)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 497 58.2414 12.4287 7066
Inferior_Fronto_Occipital_Fasciculus_R 279 58.0932 6.96596 2214
Corpus_Callosum_Tapetum 256 56.7031 8.99339 3602
Corticospinal_Tract_R 166 54.9518 6.40399 1770
Cingulum_Frontal_Parietal_L 162 58.963 5.09257 1201
Cerebellum_R 92 54.0652 4.27215 775
Corpus_Callosum_Forceps_Major 70 60.3714 5.38898 1377
Medial_Lemniscus_R 46 55.087 5.02851 1094
Cerebellum_L 38 52.7368 3.3253 458
Corticostriatal_Tract_Superior_R 28 53.0714 4.00325 668
Cingulum_Frontal_Parahippocampal_L 22 56.3636 3.23754 464
Cingulum_Frontal_Parietal_R 22 55.5455 2.83247 350
Corticopontine_Tract_Parietal_R 21 53.8095 2.98673 377
Inferior_Longitudinal_Fasciculus_L 13 54 2.66847 302
Cingulum_Parolfactory_L 12 56.6667 2.75989 339
Corpus_Callosum_Forceps_Minor 10 52.8 2.54218 268



Figures


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with Maze Path Eff in men


Glass brain displaying tracts that had AD positively and negatively correlated with Maze Path Eff in men







Women

Positive Correlations ( FDR= 0.008333)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 28 52.2911 3.52737 511
Cerebellum_R 18 50.785 3.16678 400



Negative Correlations (FDR= 0.003215)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 155 53.9739 6.48725 1784
Fornix_R 20 55.4092 3.25826 462
Thalamic_Radiation_Superior_L 19 55.38 3.1369 428



Figures


Slice overlay image displaying ROIs with tracts that had AD positively correlated with Maze Path Eff women


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with Maze Path Eff in women


Glass brain displaying tracts that had AD positively and negatively correlated with Maze Path Eff in women







Pre

Positive Correlations ( FDR= 1.000000)

No significant tracts



Negative Correlations (FDR= 0.016484)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 426 56.3991 8.47291 3180
Fornix_R 281 55.395 7.11747 2204
Thalamic_Radiation_Superior_L 96 54.4583 5.45982 1275
Cerebellum_L 32 52.0625 3.99622 653
Cingulum_Frontal_Parietal_L 22 53.0909 3.48354 506



Figures


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with Maze Path Eff in pre-menopausal women


Glass brain displaying tracts that had AD positively and negatively correlated with Maze Path Eff in pre menopausal women







Peri

Positive Correlations ( FDR= 0.000991)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 330 54.4424 6.1704 1628
Fornix_L 97 53.7732 5.27911 1177
Cerebellum_R 26 53.8462 3.54344 531
Cerebellum_L 21 52.8571 3.12342 405



Negative Correlations (FDR= 0.001513)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 193 54.2176 7.4003 2332
Cerebellum_L 58 53.8621 5.07606 1090
Middle_Cerebellar_Peduncle 22 51 3.44001 474



Figures


Slice overlay image displaying ROIs with tracts that had AD positively correlated with Maze Path Eff in peri menopausal women


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with Maze Path Eff in peri menopausal women


Glass brain displaying tracts that had AD positively and negatively correlated with Maze Path Eff in peri menopausal women







Post

Positive Correlations ( FDR= 0.001510)
Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 894 53.2237 9.67885 3916
Cerebellum_R 245 52.6939 7.93832 2608
Fornix_R 39 54.5641 3.70101 587



Negative Correlations (FDR= 0.019694)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 111 52.955 6.45321 1732
Fornix_R 49 53.7551 3.9328 653
Corpus_Callosum_Tapetum 31 56.8387 4.68539 980
Corpus_Callosum_Forceps_Major 16 51.75 3.41138 473
Medial_Lemniscus_R 11 53.6364 2.24862 213
Thalamic_Radiation_Posterior_L 10 52.4 2.69991 300
Middle_Cerebellar_Peduncle 10 52.4 1.83779 139



Figures


Slice overlay image displaying ROIs with tracts that had AD positively correlated with Maze Path Eff in post menopausal women


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with Maze Path Eff in post-menopausal women


Glass brain displaying tracts that had AD positively and negatively correlated with Maze Path Eff in post-menopausal women







Peri and Post

Positive Correlations ( FDR= 0.003250)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 404 52.3762 8.44823 2936
Cerebellum_R 41 52.878 4.18105 726
Fornix_R 37 55.4595 3.63961 577



Negative Correlations (FDR= 0.408696)

No Significant Correlations



Figures


Slice overlay image displaying ROIs with tracts that had AD negatively correlated with Maze Path Eff in peri and post-menopausal women


Glass brain displaying tracts that had AD positively and negatively correlated with Maze Path Eff in peri and post-menopausal women







RD

All Subjects

Positive Correlations ( FDR= 0.500000)

No Significant Correlations



Negative Correlations (FDR= 0.013981)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Longitudinal_Fasciculus_R 535 54.6953 9.71812 4057
Inferior_Fronto_Occipital_Fasciculus_R 383 52.0261 9.74954 3884
Corticostriatal_Tract_Posterior_R 366 53.6448 9.67274 3942
Middle_Longitudinal_Fasciculus_R 148 53.027 6.07693 1538
Corpus_Callosum_Tapetum 126 54.9841 6.7404 1962
Fornix_R 46 53.1739 3.32603 462
Inferior_Fronto_Occipital_Fasciculus_L 29 58.2759 3.52277 568
Inferior_Longitudinal_Fasciculus_L 19 54.1053 3.40611 493
Corpus_Callosum_Body 17 51.2941 2.80069 316



Figures


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze Path Eff


Glass brain displaying tracts that had RD positively and negatively correlated with Maze Path Eff







Men

Positive Correlations ( FDR= 0.321383)

No Significant Correlations

Negative Correlations (FDR= 0.005025)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Arcuate_Fasciculus_R 53 55.3585 5.06862 1117
Corpus_Callosum_Tapetum 27 54.3704 4.68679 938
Middle_Longitudinal_Fasciculus_R 25 53.52 4.14157 721
Corticostriatal_Tract_Posterior_R 24 53.4167 3.37191 477



Figures


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze Path Eff in men


Glass brain displaying tracts that had RD negatively correlated with Maze Path Eff in men







Women

Positive Correlations ( FDR= 0.007353)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 50 51.76 4.65792 882



Negative Correlations (FDR=0.000514)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 349 55.7479 8.31196 3025
Inferior_Longitudinal_Fasciculus_R 223 53.0942 7.66504 2450
Inferior_Fronto_Occipital_Fasciculus_R 189 51.7249 7.77851 2458
Fornix_R 128 54.5156 6.06698 1576
Cerebellum_L 96 52.7292 6.30633 1647
Corticostriatal_Tract_Posterior_R 68 52.2059 5.01203 1030
Thalamic_Radiation_Superior_L 62 55.0323 4.84596 1015
Corpus_Callosum_Tapetum 11 50.9091 2.64155 279



Figures


Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze Path Eff in women


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze Path Eff in women


Glass brain displaying tracts that had RD positively and negatively correlated with Maze Path Eff in women







Pre

Positive Correlations ( FDR= 1.000000)

No Significant correlations



Negative Correlations (FDR= 0.021390)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1230 55.1398 10.1505 4462
Inferior_Fronto_Occipital_Fasciculus_R 817 54.6952 11.439 5621
Inferior_Longitudinal_Fasciculus_R 717 57.7099 10.8472 5333
Fornix_R 479 55.1441 8.02328 2788
Corticostriatal_Tract_Posterior_R 103 55.301 6.41791 1789
Thalamic_Radiation_Superior_L 102 54.2941 5.5299 1304
Corpus_Callosum_Tapetum 79 56.4557 7.18339 2288
Middle_Longitudinal_Fasciculus_R 49 54.5306 4.06298 707
Cerebellum_L 43 51.907 5.07259 1049
Corpus_Callosum_Forceps_Major 25 53.2 4.13958 716
Thalamic_Radiation_Superior_R 16 56.625 2.58422 297
Cingulum_Frontal_Parietal_L 12 53.8333 1.94531 160



Figures


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze Path Eff in pre- menopausal women


Glass brain displaying tracts that had RD negatively correlated with Maze Path Eff in pre women







Peri

Positive Correlations ( FDR= 0.001243)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 571 55.9299 6.98953 2146
Fornix_L 275 56.8945 7.12271 2267
Cerebellum_R 90 52.2444 6.15404 1554
Cingulum_Frontal_Parietal_L 19 56 2.86493 361



Negative Correlations (FDR= 0.001323)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 222 53.5405 8.34305 2927
Cerebellum_R 109 55.5596 6.19189 1673
Middle_Cerebellar_Peduncle 14 51.1429 2.7329 300



Figures


Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze Path Eff in peri menopausal women


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze Path Eff in peri menopausal women


Glass brain displaying tracts that had RD positively and negatively correlated with Maze Path Eff in peri menopausal women







Post

Positive Correlations ( FDR= 0.007082)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 688 52.8459 9.26525 3563
Cerebellum_R 184 52.8587 6.01094 1500
Fornix_R 76 53.7895 4.90403 1016



Negative Correlations (FDR= 0.006757)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 147 53.3333 6.87698 1981
Cerebellum_R 115 53.4261 5.9128 1467
Fornix_R 105 54.7619 4.83391 1005
Corticostriatal_Tract_Posterior_R 63 54.6349 5.15207 1139
Middle_Longitudinal_Fasciculus_R 59 54.7797 5.22149 1173
Thalamic_Radiation_Posterior_R 51 53.9216 4.62017 904
Inferior_Longitudinal_Fasciculus_L 36 55.7222 4.54993 906
Inferior_Fronto_Occipital_Fasciculus_R 35 55.1429 4.95424 1063
Corpus_Callosum_Body 29 53.3103 4.22386 747
Corpus_Callosum_Tapetum 28 60.8571 4.0319 777
Inferior_Longitudinal_Fasciculus_R 22 57.8182 4.56665 947
Frontal_Aslant_Tract_L 16 52.75 2.79651 324
Corticostriatal_Tract_Posterior_L 11 55.0909 2.93609 373
Thalamic_Radiation_Posterior_L 11 53.8182 2.80681 333



Figures


Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze Path Eff in post menopausal women


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze Path Eff in post-menopausal women


Glass brain displaying tracts that had RD positively and negatively correlated with Maze Path Eff in post-menopausal women







Peri and Post

Positive Correlations ( FDR= 0.006927)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 343 55.1837 5.94149 1530
Cerebellum_L 237 51.3671 7.79602 2452
Cerebellum_R 82 52.7561 5.3546 1188



Negative Correlations (FDR= 0.188596)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 79 52.4304 5.18486 1107
Middle_Cerebellar_Peduncle 14 51.5714 2.65261 285



Figures


Slice overlay image displaying ROIs with tracts that had RD positively correlated with Maze Path Eff in peri and post menopausal women


Slice overlay image displaying ROIs with tracts that had RD negatively correlated with Maze Path Eff in peri and post-menopausal women


Glass brain displaying tracts that had RD positively and negatively correlated with Maze Path Eff in peri and post-menopausal women